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Addressing Patient ConcernsIn addition to effectiveness, patients are concerned about the level of irritation they may experience while on acne therapy.Some patients who used tretinoin in the past may be reluctant to try it again. For these patients, a gentler formulation, such as adapalene, might be the best first choice for a topical retinoid.Women who wear cosmetics might also prefer adapalene because its gel formulation is compatible with most makeups, allowing easy and smooth application with no pilling.

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